Natural Green Coating Inhibits Adhesion of Clinically Important Bacteria
- Trentin, Danielle S. [ Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Brazil ] [ Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Brazil ]
- Silva, Denise B. [ Núcleo de Pesquisas em Produtos Naturais e Sintéticos (NPPNS), Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Brazil ]
- Frasson, Amanda P. [ Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Brazil ]
- Rzhepishevska, Olena [ Department of Chemistry, Umeå University, Sweden ]
- Silva, Márcia V. da [ Centro de Ciências Biológicas and Departamento de BioquÃmica, Universidade Federal de Pernambuco, Brazil ]
- Pulcini, Elinor de L. [ Montana State University: Center for Biofilm Engineering ]
- James, Garth [ Montana State University: Center for Biofilm Engineering ]
- Soares, Gabriel V. [ Instituto de FÃsica, Universidade Federal do Rio Grande do Sul, Brazil ]
- Tasca, Tiana [ Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Brazil ]
- Ramstedt, Madeleine [ Department of Chemistry, Umeå University, Sweden ]
- Giordani, Raquel B. [ Centro de Ciências da Saúde, Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Brazil ]
- Lopes, Norberto P. [ Núcleo de Pesquisas em Produtos Naturais e Sintéticos (NPPNS), Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Brazil ]
- Macedo, Alexandre J. [ Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Brazil ] [ Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Brazil ]
Despite many advances, biomaterial-associated infections continue to be a major clinical problem. In order to minimize bacterial adhesion, material surface modifications are currently being investigated and natural products possess large potential for the design of innovative surface coatings. We report the bioguided phytochemical investigation of Pityrocarpa moniliformis and the characterization of tannins by mass spectrometry. It was demonstrated that B-type linked proanthocyanidins-coated surfaces, here termed Green coatings, reduced Gram-positive bacterial adhesion and supported mammalian cell spreading. The proposed mechanism of bacterial attachment inhibition is based on electrostatic repulsion, high hydrophilicity and the steric hindrance provided by the coating that blocks bacterium-substratum interactions. This work shows the applicability of a prototype Green-coated surface that aims to promote necessary mammalian tissue compatibility, while reducing bacterial colonization.